Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial

Kyoto University Substance (KUS) 121, an ATPase inhibitor of valosin-containing protein, is a novel neuroprotectant. We tested the safety and effectiveness of KUS121 in patients with acute central retinal artery occlusion (CRAO). We conducted an investigator-initiated, first-in-humans, phase 1/2 cli...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ikeda, Hanako Ohashi, Muraoka, Yuki, Hata, Masayuki, Sumi, Eriko, Ikeda, Takafumi, Nakagawa, Takayuki, Abe, Hiroyasu, Tada, Harue, Morita, Satoshi, Kakizuka, Akira, Yoshimura, Nagahisa, Tsujikawa, Akitaka
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018138/
https://ncbi.nlm.nih.gov/pubmed/32053676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229068
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