Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration

Retinitis pigmentosa (RP) is one of the leading causes of adult blindness and has no established therapy. We have shown that valosin-containing protein (VCP) modulators, Kyoto University Substances (KUSs), ameliorated abnormally low ATP levels by inhibiting the ATPase of VCP, thereby protected sever...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Hasegawa, Tomoko, Muraoka, Yuki, Ikeda, Hanako Ohashi, Tsuruyama, Tatsuaki, Kondo, Mineo, Terasaki, Hiroko, Kakizuka, Akira, Yoshimura, Nagahisa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977562/
https://ncbi.nlm.nih.gov/pubmed/27503804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31184
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