The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

A central and still open question regarding the pathogenesis of autoimmune diseases, such as type 1 diabetes, concerns the processes that underlie the generation of MHC-presented autoantigenic epitopes that become targets of autoimmune attack. Proteasomal degradation is a key step in processing of p...

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Publicat a:PLoS One
Autors principals: Khilji, Muhammad Saad, Verstappen, Danielle, Dahlby, Tina, Burstein Prause, Michala Cecilie, Pihl, Celina, Bresson, Sophie Emilie, Bryde, Tenna Holgersen, Keller Andersen, Phillip Alexander, Klindt, Kristian, Zivkovic, Dusan, Bousquet-Dubouch, Marie-Pierre, Tyrberg, Björn, Mandrup-Poulsen, Thomas, Marzec, Michal Tomasz
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018053/
https://ncbi.nlm.nih.gov/pubmed/32053590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222432
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