GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transcriptional co-activators YAP/TAZ. We were interested...

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Pubblicato in:PLoS One
Autori principali: Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018035/
https://ncbi.nlm.nih.gov/pubmed/32053631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228195
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