GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transcriptional co-activators YAP/TAZ. We were interested...

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書誌詳細
出版年:PLoS One
主要な著者: Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018035/
https://ncbi.nlm.nih.gov/pubmed/32053631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228195
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