Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P(2) and S1P(3) Receptors and Smad-independent Signaling

Synthetic sphingosine 1-phosphate receptor 1 modulators constitute a new class of drugs for the treatment of autoimmune diseases. Sphingosine 1-phosphate (S1P) signaling, however, is also involved in the development of fibrosis. Using normal human lung fibroblasts, we investigated the induction of f...

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Detalhes bibliográficos
Main Authors: Sobel, Katrin, Menyhart, Katalin, Killer, Nina, Renault, Bérengère, Bauer, Yasmina, Studer, Rolf, Steiner, Beat, Bolli, Martin H., Nayler, Oliver, Gatfield, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663507/
https://ncbi.nlm.nih.gov/pubmed/23589284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426726
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