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A nuclear phosphoinositide kinase complex regulates p53
The tumor suppressor p53 (TP53) protects the genome against cellular stress and is frequently mutated in cancer. Mutant p53 acquires gain-of-function oncogenic activities that are dependent on its enhanced stability. However, the mechanisms by which nuclear p53 is stabilized are poorly understood. H...
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| Vydáno v: | Nat Cell Biol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7017954/ https://ncbi.nlm.nih.gov/pubmed/30886346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0297-2 |
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