GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via allosteric modulation are largely un-known. W...

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Publicado no:Cell Rep
Main Authors: Hanson, Jesse E., Ma, Keran, Elstrott, Justin, Weber, Martin, Saillet, Sandrine, Khan, Abdullah S., Simms, Jeffrey, Liu, Benjamin, Kim, Thomas A., Yu, Gui-Qiu, Chen, Yelin, Wang, Tzu-Ming, Jiang, Zhiyu, Liederer, Bianca M., Deshmukh, Gauri, Solanoy, Hilda, Chan, Connie, Sellers, Benjamin D., Volgraf, Matthew, Schwarz, Jacob B., Hackos, David H., Weimer, Robby M., Sheng, Morgan, Gill, T. Michael, Scearce-Levie, Kimberly, Palop, Jorge J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017907/
https://ncbi.nlm.nih.gov/pubmed/31940483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.030
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