Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models

Extensive evidence implicates GluN2B-containing NMDA receptors (GluN2B-NMDARs) in excitotoxic-insult-induced neurodegeneration and amyloid β (Aβ)-induced synaptic dysfunction. Therefore, inhibiting GluN2B-NMDARs would appear to be a potential therapeutic strategy to provide neuroprotection and impro...

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Vydáno v:J Neurosci
Hlavní autoři: Hanson, Jesse E., Meilandt, William J., Gogineni, Alvin, Reynen, Paul, Herrington, James, Weimer, Robby M., Scearce-Levie, Kimberly, Zhou, Qiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608240/
https://ncbi.nlm.nih.gov/pubmed/24920631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5106-13.2014
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