Novel Engraftment and T Cell Differentiation of Human Hematopoietic Cells in ART(−/−) IL2RG(−/Y) SCID Pigs

Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal model. Swine are anatomically and physiologically more similar to humans than mice, making them an invaluable tool for preclinical regenerative medicine and cancer research. One essential step in further developing t...

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Udgivet i:Front Immunol
Main Authors: Boettcher, Adeline N., Li, Yunsheng, Ahrens, Amanda P., Kiupel, Matti, Byrne, Kristen A., Loving, Crystal L., Cino-Ozuna, A. Giselle, Wiarda, Jayne E., Adur, Malavika, Schultz, Blythe, Swanson, Jack J., Snella, Elizabeth M., Ho, Chak-Sum (Sam), Charley, Sara E., Kiefer, Zoe E., Cunnick, Joan E., Putz, Ellie J., Dell'Anna, Giuseppe, Jens, Jackie, Sathe, Swanand, Goldman, Frederick, Westin, Erik R., Dekkers, Jack C. M., Ross, Jason W., Tuggle, Christopher K.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017803/
https://ncbi.nlm.nih.gov/pubmed/32117254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00100
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