MY-5445, a phosphodiesterase type 5 inhibitor, resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic anticancer drugs

The overexpression of one or multiple ATP-binding cassette (ABC) transporters such as ABCB1, ABCC1 or ABCG2 in cancer cells often leads to the development of multidrug resistance phenotype and consequent treatment failure. Therefore, these transporters constitute an important target to improve the t...

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Publicado en:Am J Cancer Res
Autores principales: Wu, Chung-Pu, Lusvarghi, Sabrina, Tseng, Pin-Jung, Hsiao, Sung-Han, Huang, Yang-Hui, Hung, Tai-Ho, Ambudkar, Suresh V
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017726/
https://ncbi.nlm.nih.gov/pubmed/32064159
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