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Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib
BACKGROUND: KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure. RESULTS:...
में बचाया:
| में प्रकाशित: | Cell Biosci |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
BioMed Central
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7017564/ https://ncbi.nlm.nih.gov/pubmed/32082541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-0377-9 |
| टैग : |
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