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Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib
BACKGROUND: KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure. RESULTS:...
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| Publicado no: | Cell Biosci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7017564/ https://ncbi.nlm.nih.gov/pubmed/32082541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-0377-9 |
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