The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to immunotherapies. A fast, inexpensive method of screening fo...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: McCord, Matthew, Steffens, Alicia, Javier, Rodrigo, Kam, Kwok-Ling, McCortney, Kathleen, Horbinski, Craig
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017562/
https://ncbi.nlm.nih.gov/pubmed/32051040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-0892-2
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