GENE-61. TEMOZOLOMIDE-INDUCED MISMATCH REPAIR INSUFFICIENCY AND HYPERMETHYLATION OF MGMT PROMOTER WITH HYPERMUTATION IN MALIGNANT GLIOMAS

INTRODUCTION: Temozolomide (TMZ) induces inactivation of the DNA mismatch repair (MMR) genes in glioma especially with methylated MGMT promoter and hence causes hypermutator phenotype at recurrence. Here we show molecular changes that occur during TMZ treatment in glioma patients and those impacts o...

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Publicado no:Neuro Oncol
Main Authors: Saito, Kuniaki, Suzuki, Kaori, Shimizu, Saki, Kobayashi, Keiichi, Shimada, Daisuke, Kume, Satoshi, Iijima, Shohei, Chiba, Tomohiro, Shibahara, Junji, Shiokawa, Yoshiaki, Nagane, Motoo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693065/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.433
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