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GENE-61. TEMOZOLOMIDE-INDUCED MISMATCH REPAIR INSUFFICIENCY AND HYPERMETHYLATION OF MGMT PROMOTER WITH HYPERMUTATION IN MALIGNANT GLIOMAS
INTRODUCTION: Temozolomide (TMZ) induces inactivation of the DNA mismatch repair (MMR) genes in glioma especially with methylated MGMT promoter and hence causes hypermutator phenotype at recurrence. Here we show molecular changes that occur during TMZ treatment in glioma patients and those impacts o...
Tallennettuna:
| Julkaisussa: | Neuro Oncol |
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| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693065/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.433 |
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