GENE-61. TEMOZOLOMIDE-INDUCED MISMATCH REPAIR INSUFFICIENCY AND HYPERMETHYLATION OF MGMT PROMOTER WITH HYPERMUTATION IN MALIGNANT GLIOMAS

INTRODUCTION: Temozolomide (TMZ) induces inactivation of the DNA mismatch repair (MMR) genes in glioma especially with methylated MGMT promoter and hence causes hypermutator phenotype at recurrence. Here we show molecular changes that occur during TMZ treatment in glioma patients and those impacts o...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Saito, Kuniaki, Suzuki, Kaori, Shimizu, Saki, Kobayashi, Keiichi, Shimada, Daisuke, Kume, Satoshi, Iijima, Shohei, Chiba, Tomohiro, Shibahara, Junji, Shiokawa, Yoshiaki, Nagane, Motoo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
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Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693065/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.433
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