PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Gliomas are the most common primary intracranial neoplasms among all brain malignancies, and the microtubule affinity regulating kinases (MARKs) have become potential drug targets for glioma. Here, we report a novel dual small-molecule inhibitor of MARK3 and MARK4, designated as PCC0208017. In vitro...

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Bibliographic Details
Published in:Acta Pharm Sin B
Main Authors: Li, Fangfang, Liu, Zongliang, Sun, Heyuan, Li, Chunmei, Wang, Wenyan, Ye, Liang, Yan, Chunhong, Tian, Jingwei, Wang, Hongbo
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016295/
https://ncbi.nlm.nih.gov/pubmed/32082974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.09.004
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