PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

The increased PD-L1 expression induces poorer prognosis in melanoma. The small molecule inhibitors of PD-1/PD-L1 pathways have been an encouraging drug development strategy because of good affinity and oral bioavailability without immunogenicity and immunotoxicities of PD-1/PD-L1 antibodies. In this...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Hu, Zhengping, Yu, Pengfei, Du, Guangying, Wang, Wenyan, Zhu, Haibo, Li, Ning, Zhao, Huijuan, Dong, Zhaoju, Ye, Liang, Tian, Jingwei
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098565/
https://ncbi.nlm.nih.gov/pubmed/32214351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228339
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