Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

BACKGROUND: Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells. Nonetheless, for patients w...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Marotte, Lucine, Simon, Sylvain, Vignard, Virginie, Dupre, Emilie, Gantier, Malika, Cruard, Jonathan, Alberge, Jean-Baptiste, Hussong, Melanie, Deleine, Cecile, Heslan, Jean-Marie, Shaffer, Jonathan, Beauvais, Tiffany, Gaschet, Joelle, Scotet, Emmanuel, Fradin, Delphine, Jarry, Anne, Nguyen, Tuan, Labarriere, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057432/
https://ncbi.nlm.nih.gov/pubmed/32001504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000311
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