CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells

Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC). TERC is constitutively expressed in all cells, whereas TERT expression is temporally and spatially regulated, such that in most adult somatic...

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Pubblicato in:Int J Mol Sci
Autori principali: Wen, Luan, Zhao, Changzhi, Song, Jun, Ma, Linyuan, Ruan, Jinxue, Xia, Xiaofeng, Chen, Y. Eugene, Zhang, Jifeng, Ma, Peter X., Xu, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014288/
https://ncbi.nlm.nih.gov/pubmed/31963842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020653
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