Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespa...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Xu, Jie, Livraghi-Butrico, Alessandra, Hou, Xia, Rajagopalan, Carthic, Zhang, Jifeng, Song, Jun, Jiang, Hong, Wei, Hong-Guang, Wang, Hui, Bouhamdan, Mohamad, Ruan, Jinxue, Yang, Dongshan, Qiu, Yining, Xie, Youming, Barrett, Ronald, McClellan, Sharon, Mou, Hongmei, Wu, Qingtian, Chen, Xuequn, Rogers, Troy D., Wilkinson, Kristen J., Gilmore, Rodney C., Esther, Charles R., Zaman, Khalequz, Liang, Xiubin, Sobolic, Michael, Hazlett, Linda, Zhang, Kezhong, Frizzell, Raymond A., Gentzsch, Martina, O’Neal, Wanda K., Grubb, Barbara R., Chen, Y. Eugene, Boucher, Richard C., Sun, Fei
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821608/
https://ncbi.nlm.nih.gov/pubmed/33232302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139813
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