Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespa...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Xu, Jie, Livraghi-Butrico, Alessandra, Hou, Xia, Rajagopalan, Carthic, Zhang, Jifeng, Song, Jun, Jiang, Hong, Wei, Hong-Guang, Wang, Hui, Bouhamdan, Mohamad, Ruan, Jinxue, Yang, Dongshan, Qiu, Yining, Xie, Youming, Barrett, Ronald, McClellan, Sharon, Mou, Hongmei, Wu, Qingtian, Chen, Xuequn, Rogers, Troy D., Wilkinson, Kristen J., Gilmore, Rodney C., Esther, Charles R., Zaman, Khalequz, Liang, Xiubin, Sobolic, Michael, Hazlett, Linda, Zhang, Kezhong, Frizzell, Raymond A., Gentzsch, Martina, O’Neal, Wanda K., Grubb, Barbara R., Chen, Y. Eugene, Boucher, Richard C., Sun, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821608/
https://ncbi.nlm.nih.gov/pubmed/33232302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139813
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