Inhibition of DNA Repair Protein Ku70 in High-Glucose Environment Aggravates the Neurotoxicity Induced by Bupivacaine in SH-SY5Y Cells

Bupivacaine, a common local anesthetic, causes serious nerve injury, especially in diabetic patients, as high glucose has been reported to enhance bupivacaine-induced neurotoxicity. However, the key regulator for synergism remains unknown. To our surprise, the expression of repair protein Ku70 is su...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Ji, Zhong-Hua, Zhou, Yu, Wang, Hui, Li, Shuang, Liang, Gen-qiang, Mao, Jun
Format: Artigo
Language:Inglês
Published: Hindawi 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013357/
https://ncbi.nlm.nih.gov/pubmed/32076604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1283214
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