High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells

Bupivacaine, a typical local anesthetic, induces neurotoxicity via reactive oxygen species regulation of apoptosis. High glucose could enhance bupivacaine-induced neurotoxicity through regulating oxidative stress, but the mechanism of it is not clear. Mitochondrial calcium uniporter (MCU), a key cha...

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Publicat a:Oxid Med Cell Longev
Autors principals: Liu, Zhong-Jie, Zhao, Wei, Lei, Hong-Yi, Xu, Hua-Li, Lai, Lu-Ying, Xu, Rui, Xu, Shi-Yuan
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398017/
https://ncbi.nlm.nih.gov/pubmed/30911349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7192798
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