Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage in a genetically engineered MPNST mouse model. Ganetespib is an injectable poten...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sarcoma
Asıl Yazarlar: Kim, AeRang, Lu, Yao, Okuno, Scott H., Reinke, Denise, Maertens, Ophélia, Perentesis, John, Basu, Mitali, Wolters, Pamela L., De Raedt, Thomas, Chawla, Sant, Chugh, Rashmi, Van Tine, Brian A., O'Sullivan, Geraldine, Chen, Alice, Cichowski, Karen, Widemann, Brigitte C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013290/
https://ncbi.nlm.nih.gov/pubmed/32089640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5784876
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