iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder caused by a point mutation in the Lamin A gene that produces the protein progerin. Progerin toxicity leads to accelerated aging and death from cardiovascular disease. To elucidate the effects of progerin on endothelial cells, we prepared...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Atchison, Leigh, Abutaleb, Nadia O., Snyder-Mounts, Elizabeth, Gete, Yantenew, Ladha, Alim, Ribar, Thomas, Cao, Kan, Truskey, George A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013250/
https://ncbi.nlm.nih.gov/pubmed/32032552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.01.005
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