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Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors

Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host cell. Here, we report the cryo-EM structures of heptameric PA channels with partially unfolded LF and EF at 4.6 and 3....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hardenbrook, Nathan J., Liu, Shiheng, Zhou, Kang, Ghosal, Koyel, Zhou, Z. Hong, Krantz, Bryan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012834/
https://ncbi.nlm.nih.gov/pubmed/32047164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14658-6
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