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RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in cl...

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Pubblicato in:eLife
Autori principali: Palace, Samantha G, Wang, Yi, Rubin, Daniel HF, Welsh, Michael A, Mortimer, Tatum D, Cole, Kevin, Eyre, David W, Walker, Suzanne, Grad, Yonatan H
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012608/
https://ncbi.nlm.nih.gov/pubmed/32011233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51407
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