The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction

BACKGROUND: Alterations to epithelial tight junctions can compromise the ability of the epithelium to act as a barrier between luminal contents and the underlying tissues, thereby increasing intestinal permeability, an early critical event in inflammatory bowel disease (IBD). Tofacitinib (Xeljanz),...

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Vydáno v:Inflamm Bowel Dis
Hlavní autoři: Sayoc-Becerra, Anica, Krishnan, Moorthy, Fan, Shujun, Jimenez, Jossue, Hernandez, Rebecca, Gibson, Kyle, Preciado, Reyna, Butt, Grant, McCole, Declan F
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic Science Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012302/
https://ncbi.nlm.nih.gov/pubmed/31751457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izz266
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