The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions

BACKGROUND AND AIMS: Loss-of-function variants in protein tyrosine phosphatase non-receptor type-2 [PTPN2] promote susceptibility to inflammatory bowel diseases [IBD]. PTPN2 regulates Janus-kinase [JAK] and signal transducer and activator of transcription [STAT] signalling, while protecting the inte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Crohns Colitis
Main Authors: Spalinger, Marianne R, Sayoc-Becerra, Anica, Ordookhanian, Christ, Canale, Vinicius, Santos, Alina N, King, Stephanie J, Krishnan, Moorthy, Nair, Meera G, Scharl, Michael, McCole, Declan F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944512/
https://ncbi.nlm.nih.gov/pubmed/32909045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjaa182
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados