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Gilteritinib induces PUMA‐dependent apoptotic cell death via AKT/GSK‐3β/NF‐κB pathway in colorectal cancer cells

As a highly potent and highly selective oral inhibitor of FLT3/AXL, gilteritinib showed activity against FLT3D835 and FLT3‐ITD mutations in pre‐clinical testing, although its role on colorectal cancer (CRC) cells is not yet fully elucidated. We examined the activity of gilteritinib in suppressing gr...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Li, Liangjun, Lin, Lin, Li, Ming, Li, Weiling
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011145/
https://ncbi.nlm.nih.gov/pubmed/31881122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14913
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