Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation

Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell proliferation, but the role of GLS2 in cancer remains poorly unde...

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Publié dans:Sci Rep
Auteurs principaux: López de la Oliva, Amada R., Campos-Sandoval, José A., Gómez-García, María C., Cardona, Carolina, Martín-Rufián, Mercedes, Sialana, Fernando J., Castilla, Laura, Bae, Narkhyun, Lobo, Carolina, Peñalver, Ana, García-Frutos, Marina, Carro, David, Enrique, Victoria, Paz, José C., Mirmira, Raghavendra G., Gutiérrez, Antonia, Alonso, Francisco J., Segura, Juan A., Matés, José M., Lubec, Gert, Márquez, Javier
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010782/
https://ncbi.nlm.nih.gov/pubmed/32042057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58264-4
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