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The common message of constraint-based optimization approaches: overflow metabolism is caused by two growth-limiting constraints

Living cells can express different metabolic pathways that support growth. The criteria that determine which pathways are selected in which environment remain unclear. One recurrent selection is overflow metabolism: the simultaneous usage of an ATP-efficient and -inefficient pathway, shown for examp...

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Detalles Bibliográficos
Publicado en:Cell Mol Life Sci
Main Authors: de Groot, Daan H., Lischke, Julia, Muolo, Riccardo, Planqué, Robert, Bruggeman, Frank J., Teusink, Bas
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010627/
https://ncbi.nlm.nih.gov/pubmed/31758233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03380-2
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