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Interplay between Constraints, Objectives, and Optimality for Genome-Scale Stoichiometric Models

High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the comprehensive study of metabolic networks. The computation of all feasible metabolic routes with these models, given stoichiometric, thermodynamic, and steady-state constraints, provides important ins...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Maarleveld, Timo R., Wortel, Meike T., Olivier, Brett G., Teusink, Bas, Bruggeman, Frank J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388735/
https://ncbi.nlm.nih.gov/pubmed/25849486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004166
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