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The common message of constraint-based optimization approaches: overflow metabolism is caused by two growth-limiting constraints

Living cells can express different metabolic pathways that support growth. The criteria that determine which pathways are selected in which environment remain unclear. One recurrent selection is overflow metabolism: the simultaneous usage of an ATP-efficient and -inefficient pathway, shown for examp...

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Bibliografske podrobnosti
izdano v:Cell Mol Life Sci
Main Authors: de Groot, Daan H., Lischke, Julia, Muolo, Riccardo, Planqué, Robert, Bruggeman, Frank J., Teusink, Bas
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010627/
https://ncbi.nlm.nih.gov/pubmed/31758233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03380-2
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