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Optimal flux spaces of genome-scale stoichiometric models are determined by a few subnetworks

The metabolism of organisms can be studied with comprehensive stoichiometric models of their metabolic networks. Flux balance analysis (FBA) calculates optimal metabolic performance of stoichiometric models. However, detailed biological interpretation of FBA is limited because, in general, a huge nu...

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Bibliographic Details
Main Authors: Kelk, Steven M., Olivier, Brett G., Stougie, Leen, Bruggeman, Frank J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419370/
https://ncbi.nlm.nih.gov/pubmed/22896812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00580
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