ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 and its partner protein FANCI. Here, we show tha...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Tan, Winnie, van Twest, Sylvie, Murphy, Vincent J., Deans, Andrew J.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010609/
https://ncbi.nlm.nih.gov/pubmed/32117957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00002
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