Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

Gene transcription profiles across tissues are largely defined by the activity of regulatory elements, most of which correspond to regions of accessible chromatin. Regulatory element activity is in turn modulated by genetic variation, resulting in variable transcription rates across individuals. The...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Keele, Gregory R., Quach, Bryan C., Israel, Jennifer W., Chappell, Grace A., Lewis, Lauren, Safi, Alexias, Simon, Jeremy M., Cotney, Paul, Crawford, Gregory E., Valdar, William, Rusyn, Ivan, Furey, Terrence S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010298/
https://ncbi.nlm.nih.gov/pubmed/31961859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008537
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