Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

BACKGROUND: The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expre...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Chappell, Grace A., Israel, Jennifer W., Simon, Jeremy M., Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G., Bodnar, Wanda, Lieb, Jason D., Crawford, Gregory E., Rusyn, Ivan, Furey, Terrence S.
Formato: Artigo
Idioma:Inglês
Publicado em: Environmental Health Perspectives 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944832/
https://ncbi.nlm.nih.gov/pubmed/29038090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP1937
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