A Phase 2 Trial of R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor (IGF-1R), in Patients With Recurrent or Refractory Rhabdomyosarcoma, Osteosarcoma, Synovial Sarcoma, and Other Soft Tissue Sarcomas: Results of a Sarcoma Alliance for Research Through Collaboration Study

BACKGROUND: Insulin-like growth factor-1 receptor (IGF-1R) is implicated in the pathogenesis of rhabdomyosarcoma (RMS), osteosarcoma (OS), and synovial sarcoma (SS). The authors conducted a multi-institutional phase 2 trial of the monoclonal antibody R1507 in patients with various subtypes of recurr...

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Publicado no:Cancer
Main Authors: Pappo, Alberto S., Vassal, Gilles, Crowley, John J., Bolejack, Vanessa, Hogendoorn, Pancras C. W., Chugh, Rashmi, Ladanyi, Marc, Grippo, Joseph F., Dall, Georgina, Staddon, Arthur P., Chawla, Sant P., Maki, Robert G., Araujo, Dejka M., Geoerger, Birgit, Ganjoo, Kristen, Marina, Neyssa, Blay, Jean-Yves, Schuetze, Scott M., Chow, Warren A., Helman, Lee J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009782/
https://ncbi.nlm.nih.gov/pubmed/24797726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28728
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