R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

PURPOSE: The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT. PATIEN...

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Główni autorzy: Pappo, Alberto S., Patel, Shreyaskumar R., Crowley, John, Reinke, Denise K., Kuenkele, Klaus-Peter, Chawla, Sant P., Toner, Guy C., Maki, Robert G., Meyers, Paul A., Chugh, Rashmi, Ganjoo, Kristen N., Schuetze, Scott M., Juergens, Heribert, Leahy, Michael G., Geoerger, Birgit, Benjamin, Robert S., Helman, Lee J., Baker, Laurence H.
Format: Artigo
Język:Inglês
Wydane: American Society of Clinical Oncology 2011
Hasła przedmiotowe:
Original Reports
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236654/
https://ncbi.nlm.nih.gov/pubmed/22025149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.34.0000
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