R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

PURPOSE: The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT. PATIEN...

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Bibliografiska uppgifter
Huvudupphovsmän: Pappo, Alberto S., Patel, Shreyaskumar R., Crowley, John, Reinke, Denise K., Kuenkele, Klaus-Peter, Chawla, Sant P., Toner, Guy C., Maki, Robert G., Meyers, Paul A., Chugh, Rashmi, Ganjoo, Kristen N., Schuetze, Scott M., Juergens, Heribert, Leahy, Michael G., Geoerger, Birgit, Benjamin, Robert S., Helman, Lee J., Baker, Laurence H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Clinical Oncology 2011
Ämnen:
Original Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236654/
https://ncbi.nlm.nih.gov/pubmed/22025149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.34.0000
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