HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients

RATIONALE: Even in antiretroviral therapy (ART) treated patients, HIV continues to play a pathogenic role in cardiovascular diseases. A possible cofactor may be persistence of the early HIV response gene Nef, which we have demonstrated recently to persist in the lungs of HIV+ patients on ART. Previo...

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Udgivet i:Circ Res
Main Authors: Chelvanambi, Sarvesh, Gupta, Samir Kumar, Chen, Xingjuan, Ellis, Bradley W., Maier, Bernhard F., Colbert, Tyler M., Kuriakose, Jithin, Zorlutuna, Pinar, Jolicoeur, Paul, Obukhov, Alexander G., Clauss, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009312/
https://ncbi.nlm.nih.gov/pubmed/31451038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315082
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