The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells

Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase (dNTPase) with a nuclear localization signal (NLS). SAMHD1 suppresses innate immune responses to viral infection and inflammatory stimuli by inhibiting the NF-κB and type I interferon (IFN-I) pat...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Qin, Zhihua, Bonifati, Serena, St. Gelais, Corine, Li, Tai-Wei, Kim, Sun-Hee, Antonucci, Jenna M., Mahboubi, Bijan, Yount, Jacob S., Xiong, Yong, Kim, Baek, Wu, Li
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008377/
https://ncbi.nlm.nih.gov/pubmed/31914403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010360
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