A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation

Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) regulates intracellular deoxynucleoside triphosphate (dNTP) levels and functions as a retroviral restriction factor through its dNTP triphosphohydrolase (dNTPase) activity. Human SAMHD1 interacts with cell cycle regulatory proteins cycl...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: St. Gelais, Corine, Kim, Sun Hee, Maksimova, Victoria V., Buzovetsky, Olga, Knecht, Kirsten M., Shepard, Caitlin, Kim, Baek, Xiong, Yong, Wu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827405/
https://ncbi.nlm.nih.gov/pubmed/29321329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01787-17
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