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First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S](0)-Like Auxiliary Cluster
The enzyme MiaB catalyzes the attachment of a methylthio (−SCH(3)) group at the C2 position of N(6)-(isopentenyl)adenosine (i(6)A) in the final step of the biosynthesis of the hypermodified tRNA nucleotide 2-methythio-N(6)-(isopentenyl)adenosine (ms(2)i(6)A). MiaB belongs to the expanding subgroup o...
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| Опубликовано в: : | J Am Chem Soc |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008301/ https://ncbi.nlm.nih.gov/pubmed/31899624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11093 |
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