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Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities for S-Adenosylmethionine: Methyl Transfer by S(N)2 Displacement and Radical Generation

The radical SAM (RS) proteins RlmN and Cfr catalyze methylation of carbons 2 and 8, respectively, of adenosine 2503 in 23S rRNA. Both reactions are similar in scope, entailing the synthesis of a methyl group partially derived from S-adenosylmethionine (SAM) onto electrophilic sp(2)-hybridized carbon...

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Autori principali: Grove, Tyler L., Radle, Matthew I., Krebs, Carsten, Booker, Squire J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596424/
https://ncbi.nlm.nih.gov/pubmed/21916495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207327v
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