Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling

Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded pr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biomed Res Int
Auteurs principaux: Zheng, Hongtu, Wu, Yuchen, Guo, Tianan, Liu, Fangqi, Xu, Ye, Cai, Sanjun
Format: Artigo
Langue:Inglês
Publié: Hindawi 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008299/
https://ncbi.nlm.nih.gov/pubmed/32076610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5958272
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