Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors (7a...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Al-Sanea, Mohammad M, Gotina, Lizaveta, Mohamed, Mamdouh FA, Grace Thomas Parambi, Della, Gomaa, Hesham A M, Mathew, Bijo, Youssif, Bahaa G M, Alharbi, Khalid Saad, Elsayed, Zainab M, Abdelgawad, Mohamed A, Eldehna, Wagdy M
Format: Artigo
Jezik:Inglês
Izdano: Dove 2020
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008064/
https://ncbi.nlm.nih.gov/pubmed/32103894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S237957
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