Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights

In this work, we present the synthesis and biological evaluation of novel series of diamide-based benzenesulfonamides 5a−h as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IX and XII. The target tumor-associated isoforms hCA IX and XII were undenia...

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Main Authors: Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Silvia Bua, Sara T. Al-Rashood, Ghada S. Hassan, Alessandro Bonardi, Abdulrahman A. Almehizia, Hamad M. Alkahtani, Amal Alharbi, Paola Gratteri, Claudiu T. Supuran
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
anticancer activity
diamide-based benzenesulfonamides
molecular docking
selective hCAIX inhibitors
synthesis
Acesso em linha:https://www.mdpi.com/1422-0067/20/10/2484
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