Synthesis and Biological Evaluation of FICZ Analogues as Agonists of Aryl Hydrocarbon Receptor

The Aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3,2-b) carbazole (FICZ, 2), a...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Wu, Hao, Liu, Binkai, Yang, Ka, Winston-McPherson, Gabrielle N., Leisten, Eric D., Vezina, Chad M., Ricke, William A., Peterson, Richard E., Tang, Weiping
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007633/
https://ncbi.nlm.nih.gov/pubmed/31952965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.126959
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